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Publicações científicas e monografias

P-MAPA-MONOGRAFIA DE PRODUTO

Preview : Monografia de Produto Farmacêutico contendo informações científicas sobre o Imunomodulador P-MAPA. Suas características fisico-quimicas, propriedades biológicas, estudos pré-clínicos e estudos em seres humanos estão detalhados e discutidos nesta Monografia de Produto, para possibilitar a compreensão e discussão do potencial terapêutico do fármaco

2nd World Conference - Ehrlich II - Nürnberg - 2008 -Structure and Antimalarial Activity of Immunomodulator P-MAPA

Preview : The P-MAPA activity against malaria ( Plasmodium chabaudi) was evaluated in groups of 7-10 C57BL/6 female mice, 5-8 week-old and pathogen-free.

Nanonization on biotechnological product: Nanocrystals and its polymorphisms

Preview : The aim of work was to compare two different nanonization processes starting from crystals of P-MAPA with size around 200μm

Immunopharmacology and Immunotoxicology - Volume 25, Number 3 / 2003

Preview : The present study examined the effects of P-MAPA, an antitumor aggregated polymer of protein magnesium ammonium phospholinoleate-palmitoleate anhydride, isolated from Aspergillus oryzae, on concanavalin A-induced spleen cell proliferation, cytokine production and on NK cell activity in Ehrlich ascites tumor-bearing mice.

Nitric Oxide 14 - 2006 Macrophage nitric oxide -NO- stimulation by an immunomodulator: P-MAPA

Preview : This study asseded the ability of P-MAPA to modulate NO production by macrophages purified from peritoneal cavity of thioglycolate-treated mice

Antiviral Research-Volume 83, Issue 2, August 2009

Punta Toro virus, has been adapted to induce a Rift Valley fever virus-like disease in C57BL/6 mice. This virus has been used as a model to study the potential role of immunomodulating substances in therapies. Here, we report findings on the use of P-MAPA as an antiviral agent in a mouse model of acute phleboviral (Punta Toro virus) disease

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Dis./Cancer

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer: Compounds that can act as agonists for toll-like receptors (TLRs) may be promising candidates for the development of drugs against infectious diseases and cancer. The present study aimed to characterize the immunomodulatory effects of P-MAPA on TLRs in vitro and in vivo, as well as to investigate its potential as adjuvant therapy in infectious diseases and cancer.

Improvement in clinical signs and cellular immunity of dogs with visceral leishmaniasis using the immunomodulator P-MAPA

Acta tropica: This study investigated the immunotherapeutic potential of the protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride immuno-modulator (P-MAPA) on canine visceral leishmaniasis.

International Immunopharmacology

International Immunopharmacology : Effects of P-MAPA immunomodulator on Toll-like receptor 2, ROS, nitric oxide, MAPKp38 and IKK in PBMC and macrophages from dogs with visceral leishmaniasis

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