10/08/2008

Toxicity and Safety -Bioavaliabilty and target organs

• Bioavaliabilty and target organs

 

• Bioavaliabilty

 

The objective was study the bioavaliabilty of P-MAPA and the target organs for the Mg2 + ions at a single dose of 750 mg/kg

 

• Pharmacocinetic parameters of single intraperitoneal injection of 750 mg/kg ( Figure 1).

 

Figure 1

 

 

• Target organs of Mg2+ ions

 

The target organs for the Mg 2+ ions as the follows :

 

• Liver; pancreas; spleen and stomach

 

• Lungs, heart; seminal  and kidneys