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28/09/2016

INTERNATIONAL BRAZ J UROL

Potential therapeutic strategies for non - muscle invasive bladder cancer based on association of intravesical immunotherapy with P-MAPA and systemic administration of cisplatin and doxorubicin

07/07/2016

Increased toll-like receptors and p53 levels regulate apoptosis and angiogenesis in non-muscle invasive bladder cancer: mechanism of action of P-MAPA biological response modifier

13/07/2015

International Journal of Clinical and Experimental Pathology-Volume 8, Number 5:4277-6011;2015

Alterations in Ubiquitin Ligase Siah-2 and its Corepressor N-CoR after P-MAPA Immunotherapy and Anti-androgen Therapy: New Therapeutic Opportunities for Non-Muscle Invasive Bladder Cancer

01/01/2014

International Immunopharmacology

International Immunopharmacology : Effects of P-MAPA immunomodulator on Toll-like receptor 2, ROS, nitric oxide, MAPKp38 and IKK in PBMC and macrophages from dogs with visceral leishmaniasis

05/05/2013

Improvement in clinical signs and cellular immunity of dogs with visceral leishmaniasis using the immunomodulator P-MAPA

Acta tropica: This study investigated the immunotherapeutic potential of the protein aggregate magnesium-ammonium phospholinoleate-palmitoleate anhydride immuno-modulator (P-MAPA) on canine visceral leishmaniasis.

18/06/2012

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Dis./Cancer

Effects of P-MAPA Immunomodulator on Toll-Like Receptors and p53: Potential Therapeutic Strategies for Infectious Diseases and Cancer: Compounds that can act as agonists for toll-like receptors (TLRs) may be promising candidates for the development of drugs against infectious diseases and cancer. The present study aimed to characterize the immunomodulatory effects of P-MAPA on TLRs in vitro and in vivo, as well as to investigate its potential as adjuvant therapy in infectious diseases and cancer

16/10/2008

P-MAPA-PRODUCT MONOGRAPH

Preview : This Monograph describes the state of art of the immunomodulator P-MAPA, that has been scientifically studied since the 80s by Brazilian, Chilean, European and American scientists.Its chemical and physical characteristics, biological properties, pre-clinical results and clinical trials results will be detailed and discussed, in order to explore its potential uses as a therapeutic

15/10/2008

Antiviral Research-Volume 83, Issue 2, August 2009

Punta Toro virus, has been adapted to induce a Rift Valley fever virus-like disease in C57BL/6 mice. This virus has been used as a model to study the potential role of immunomodulating substances in therapies. Here, we report findings on the use of P-MAPA as an antiviral agent in a mouse model of acute phleboviral (Punta Toro virus) disease

12/10/2008

Immunopharmacology and Immunotoxicology - Volume 25, Number 3 / 2003

Preview :The present study examined the effects of P-MAPA, an antitumor aggregated polymer of protein magnesium ammonium phospholinoleate-palmitoleate anhydride, isolated from Aspergillus oryzae, on concanavalin A-induced spleen cell proliferation, cytokine production and on NK cell activity in Ehrlich ascites tumor-bearing mice.

11/10/2008

Nanonization on biotechnological product: Nanocrystals and its polymorphisms-7 th Brazilian MRS Meeting 2008

Preview : The aim of present work was to compare two different nanonization processes starting from crystals of P-MAPA with size around 200μm

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